Preserving information while respecting privacy through an information theoretic framework for synthetic health data generation. NPJ Digit Med. 8(1):49.
Nos publications
Depuis sa création, l’Institut Roche a mis son expertise au profit de nombreuses publications scientifiques.
Consistent clinical factor VIII equivalency is unlikely for non-factor therapies in hemophilic miceHaematologica
Sefiane T, McCluskey G, Clavel M, Maynadié H, Peyron I, David T, Brochier C, Saller F, Khamari M, Denis CV, Christophe OD, Lenting PJ, Muczynski V, Casari C.( 2025)
https://doi.org/10.3324/haematol.2024.286982In vitro pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against Acinetobacter baumannii Antimicrob Agents Chemother. 69(5):e0153524
Lacroix M, Moreau J, Zampaloni C, Bissantz C, Mirfendereski H, Shirvani H, Marchand S, Couet W, Chauzy A. (2025)
https://doi.org/10.1038/s41746-025-01431-6Hyperglycemia and circadian disruption lead to retinal dysfunction in a stabilized colony of the fat sand rat Psammomys obesus Biochim Biophys Acta Mol Basis Dis. 1870(4):167118
Estay-Ahumada CE, Verra DM, Roux M, Sassone F, Felder-Schmittbuhl MP, Klopp C, Ciocca D, Moal ML, Hicks D. (2024)
https://doi.org/10.1016/j.bbadis.2024.167118Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab. J Thromb Haemost 22(1):112-125
Atsou S, Schellenberg C, Lagrange J, Lacolley P, Lenting PJ, Denis CV, Christophe OD, Regnault V.. (2024).
https://doi.org/10.1016/j.jtha.2023.09.017Impact of covariate model building methods on their clinical relevance evaluation in population pharmacokinetic analyses: comparison of the full model, stepwise covariate model (SCM) and SCM+ approaches. J Pharmacokinet Pharmacodyn 51(6):653-670.
Philipp, M., Buatois, S., Retout, S, Mentré F (2024).
https://doi.org/10.1007/s10928-024-09911-0Simulation-based evaluation of the Pharmpy Automatic Model Development tool for population pharmacokinetic modeling in early clinical drug development CPT Pharmacometrics Syst Pharmacol (10):1707-1721
Duvnjak Z, Schaedeli Stark F, Cosson V, Retout S, Schindler E, Abrantes JA (2024)
https://doi.org/10.1002/psp4.13213Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu-like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll-like receptor 7 agonist ruzotolimod Clinical and Translational Science. (8):e13896
Jiang, Q., Zhang, Y., Duan, D., Retout, S., Upmanyu, R., Glavini, K., Triyatni, M., Zhu, Y., Grippo, J., Jin, Y (2024).
https://doi.org/10.1111/cts.13896Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii. Int J Antimicrob Agents. 64(1):107189.