Lead Principal Scientist

Myriam Ly Le Moal

Neurosciences, Rare Diseases

“Only those who are crazy enough to think they can change the world actually do.”
– Henri Dunant, Founder of the Red Cross.

“Advancing neuroscience and rare disease research requires vision, strategic insight, and the ability to unite top scientific talent to address complex challenges. As a Lead Principal Scientist at Institut Roche, I develop and lead high-impact collaborations between industry and academia, ensuring that cutting-edge research translates into meaningful advancements for patients. With expertise in translational neuroscience, AI-driven biomedical research, and strategic R&D partnerships, I work at the intersection of science and innovation, identifying opportunities where emerging technologies accelerate discovery.”

Your role at Institut Roche and brief presentation of your professional background:

My background combines scientific expertise, business acumen, and communication strategy, shaped through extensive training in business administration and scientific journalism alongside my PhD in neuroscience from Pierre & Marie Curie University. Early in my career, I worked at Inserm, leading large-scale healthcare data projects across 83 medical centers, with a focus on data quality, integration, and analytics. At Institut Pasteur, I played a pivotal role in structuring high-profile research consortia and securing competitive innovation funding. Among these was the Inception program, a major initiative leveraging artificial intelligence, machine learning, and multi-omics approaches to better understand the emergence of diseases and uncover new therapeutic pathways. Inception’s broad scope—spanning multiple institutions and research disciplines—has set a new benchmark for how AI can drive biomedical innovation.
Since 2016, at Institut Roche, I have been dedicated to building strategic alliances that bridge fundamental research and pharmaceutical R&D. My role involves identifying promising scientific opportunities, navigating the complexities of academic-industry collaboration, and ensuring that partnerships lead to concrete advances in neuroscience and rare disease treatment. AI and data science are transforming the way we approach discovery, and I am particularly committed to integrating these technologies into collaborative research and R&D processes and frameworks.
I firmly believe that the most significant breakthroughs happen when expertise, data, and technology converge. By fostering synergies across disciplines, I strive to create the conditions for scientific excellence to thrive—delivering not only knowledge but real solutions for patients.

 

My Focus at Institut Roche:

Neuroscience and rare diseases Research partnerships, alliances set up and management.

  1. Estay-Ahumada CE, et al. (2024) “Hyperglycemia and circadian disruption lead to retinal dysfunction in a stabilized colony of the fat sand rat Psammomys obesus.” Biochim Biophys Acta Mol Basis Dis. 1870(4):167118.
  2. Lefebvre A, et al. (2023) “Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways”. Autism Res. 364-378.
  3. Laidi C, et al. (2023) “Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder.” Autism Res.16(2):280-293.
  4. Lefebvre A, et al. (2023) “Exploring the multidimensional nature of repetitive and restricted behaviors and interests (RRBI) in autism: neuroanatomical correlates and clinical implications.” Mol Autism.14(1):45.
  5. Annoussamy, M., et al. (2021). “Natural history of Type 2 and 3 spinal muscular atrophy: 2-year NatHis-SMA study.” Ann Clin Transl Neurol 8(2): 359-373.
  6. Baltazar, M., et al. (2021). “”Reading the Mind in the Eyes” in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study.” Autism Res 14(2): 380-388.
  7. Amestoy, A., et al. (2021). “Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR).” Mol Autism 12(1): 71.
  8. Lefebvre, A., et al. (2021). “Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands.” Autism Res 14(11): 2373-2382.
  9. Briot, K., et al. (2020). “Social Anxiety in Children and Adolescents With Autism Spectrum Disorders Contribute to Impairments in Social Communication and Social Motivation.” Front Psychiatry 11: 710.
  10. Laidi, C., et al. (2019). “Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.” J Autism Dev Disord 49(4): 1402-1409.
  11. Bennabi, M., et al. (2019). “Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?” Mol Autism 10: 22.
  12. d’Albis, M. A., et al. (2018). “Local structural connectivity is associated with social cognition in autism spectrum disorder.” Brain 141(12): 3472-3481.
  13. M. Ly, B. Delatour . Particular types of beta-amyloid oligomers are formed in Alzheimer’s disease-like physiopathological conditions Alzheimer’s and Dementia 07/2013; 9(4):P196. 17.47 Impact Factor
  14. M. Ly, C. Delarasse, B. Delatour. APPxPS1dE9 mice display neuronal dysfunction at an asymptomatic state of amloïdosis. Alzheimer’s and Dementia 07/2013; 9(4):P712. 17.47 Impact Factor
  15. S. Epelbaum, P. Lacor, M. Ly, C. Duyckaerts, B. Delatour. Acute functional and morphological impact of Aß oligomers. Alzheimer’s and Dementia 07/2012; 8(4):P297. DOI:10.1016/j.jalz.2012.05.802 · 17.47 Impact Factor
  16. Faure, L. Verret, B. Bozon, N. El Tannir El Tayara, M. Ly, F. Kober, M. Dhenain, C. Rampon, B. Delatour. (2011). Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer’s disease. Neurobiology of Aging 03/2011; 32(3) 4.85 Impact Factor
  17. M. Ly, P. Lacor, A. Krezymon, C. Rampon, B. Delatour, C. Duyckaerts. Natural history of Aßplaque formation: oligomers accumulation precedes fibrillar deposits, Alzheimer’s and Dementia 07/2011; 7(4).
  18. B. Delatour, M. Ly, C. Duyckaerts. Functional correlations of intracellular Aß peptide in transgenic mouse models Alzheimer’s and Dementia 07/2011; 7(4). 17.47 Impact Factor
  19. Delatour, M. Ly, C. Duyckaerts (2010) Aggregated versus soluble and intracellular species of the amyloid ß peptide: lessons from the APPxPS1-Ki model Alzheimer’s and Dementia 07/2010; 6(4).
  20. Le Cudennec, A. Faure, M. Ly, B. Delatour (2008). One-year longitudinal evaluation of sensorimotor functions in APP751SL transgenic mice. Genes Brain and Behavior 03/2008; 7 Suppl 1:83-91.
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